Current Research Projects

Nearly all faculty members are engaged in clinical or basic neuroscience research. Residents are encouraged to participate in research.

Angeline Andrew, PhD

  • Environmental factors linked with kidney cancer.

Jillian Belmont, DNP, MSN, APRN, AGACNP

  • A Retrospective Data Review: Identify risk factors and outcomes affecting quality of life in patients discharged from hospital to home after stroke, at a major rural academic tertiary-care center.

Kris Bujarski, MD – Epilepsy

  • Stereotactic Laser Ablation for Temporal Lobe Epilepsy (SLATE)
  • Modulation of emotion perception in humans via amygdala stimulation.
  • Human Intracranial Electrophysiology
  • Safety and Feasibility of Accelerated Low-Frequency Transcranial Magnetic Stimulation for Medication-Resistant Depression in Patients with Epilepsy

Jeffrey Cohen, MD - Neuromuscular diseases

Healy ALS Platform Trials

  • HEALEY ALS Platform Trial - Regimen A (zilucoplan)
  • HEALEY ALS Platform Trial - Regimen D (Pridopidine)
  • HEALEY ALS Platform Trial- Regimen B (Verdiperstat)
  • HEALEY ALS Platform Trial- Regimen C (CNM-Au8)

George Culler, MD – Epilepsy

  • Retrospective case review of patients undergoing lumbar spinal surgery with erector spinae plane block (ESPB) and concurrent intraoperative neurophysiological monitoring (IONM)

Mary Feldman, DO - Movement Disorders

  • A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Study to Evaluate Safety, Tolerability and Efficacy of Orally Administered ENT-01 for the Treatment of Parkinson’s Disease-Related Constipation (KARMET)
  • A Multicenter, Non-Randomized, Open-Label Study to Evaluate the Safety and Efficacy of Orally Administered ENT-01 in Improving Constipation and Neurologic Symptoms in Patients with Parkinson’s disease and Constipation over a 14-week Period
    Abbott DBS Post-Market Study of Outcomes for Indications over Time
    Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation

Francesca Gilli, MS, PhD

  • Single-cell and network analyses to unravel Multiple Sclerosis inflammation complexity

Barbara Jobst, MD - Epilepsy

  • Early Feasibility Study of Thalamic Stimulation to Prevent Impaired Consciousness in Epilepsy
  • RNS System Responsive Thalamic Stimulation for Primary Generalized Seizures Study
  • Dartmouth Hitchcock Epilepsy Center Cortical Stimulation Mapping Registry
  • Multicenter Retrospective Study of Patients Treated with Depth Leads in the Neocortex with the RNS System
  • HOBSCOTCH Program Evaluation, Quality Assurance and Improvement Project (Home-Based Self-management and COgnitive Training CHanges lives)
  • Memory, epilepsy and brain stimulation: Oscillatory patterns during real-world navigation and free recall in chronically implanted humans
  • Evaluating the clinical course of patients with epilepsy
  • HOme-Based Self-management and COgnitive Training CHanges lives (HOBSCOTCH) - Post-Traumatic Epilepsy (PTE)
  • HOBSCOTCH: HOme Based Self-management and COgnitive Training CHanges Lives
  • A Multi-Center Retrospective Study of Surgical Approach and Clinical Outcomes in Patients Implanted in the Insula with the RNS? System
  • NeuroPace RNS System Post-Approval Study in Epilepsy
  • Network dynamics in human epilepsy: a retrospective investigation on intracranial E
  • Multicenter Retrospective Study of Neocortical Patients with the RNS System: What is the Role of the Epileptogenic Zone?
  • Retrospective SUDEP at Epilepsy Centers: A Case-Control Study

Erik Kobylarz MD, PhD – Epilepsy/IOM

  • A device to detect and quantify seizures using non-cerebral sensor modalities.

Victoria Lawson, MD – Neuromuscular Medicine

  • Neuromuscular Observational Research (MOVR) Data Hub

Stephen Lee, MD, PhD - Movement disorders

  • An Open-label Extension of Study M15-741 to Evaluate the Safety and Tolerability of 24-hour Daily Exposure of Continuous Subcutaneous Infusion of ABBV-951 in Subjects With Parkinson's Disease

Timothy Lukovits, MD – Stroke

  • A multicenter, randomized, placebo controlled, double-blind, parallel group and event driven Phase 3 study of the oral FXIa inhibitor asundexian (BAY 2433334) for the secondary prevention of ischemic stroke in adult patients with an acute non-cardioemboli
  • Stroke Patient Management Tool
  • Zeit Alert for Stroke at Home
  • Neuro-AFib Study ? Retrospective Phase (Phase I) Data Abstraction Protocol

Richard Morse, MD - Pediatric neurology

  • A Superiority Study to Compare the Effect of Panzyga versus Placebo in Patients with Pediatric Acute-Onset Neuropsychiatric Syndrome.
  • ZX008 Expanded Access Program-Dravet Syndrome Treatment Plan
  • United States Caribsmate Expanded Access Program (EAP)
  • Treatment Guidelines for Patients with Lennox-Gastaut Syndrome (LGS)
  • Phase I, Open-Label Study of Carisbamate in Adult and Pediatric Subjects with Lennox-Gastaut Syndrome
  • Phase I, Open-Label, Pharmacokinetic, Dose-Escalation Study of Carisbamate in Adult and Pediatric Subjects with Lennox-Gastaut Syndrome
  • “A Randomized, Dose-Finding and Confirmatory, Double-Blind, Placebo-Controlled, Parallel-Group Multicenter Study with A 2-Stage Adaptive Design and Randomized Withdrawal to Evaluate the Efficacy, Safety, and Tolerability of Brivaracetam as Monotherapy

Andrew Pachner, MD – Neuro Immunology

  • Biomarker associated treatment of initial MS event with Ofatumumab

Nathaniel Robbins, MD – Clinical Neurophysiology

  • A Study to Assess Video Hand Opening Time and Ambulation in Healthy Volunteers and Individuals with Myotonic Dystrophy Type 1
  • Epilepsy, anti-epileptic medications, and quality of life in people living with epilepsy

Vijay Renga, MD – Clinical Neurophysiology

  • Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II)

Diana Rojas-Soto, MD - Stroke

  • Cardiac Abnormalities in Stroke Prevention and risk of Recurrence (CASPR): A multi-center observational cohort study

Lindsay Schommer, MSN, APRN

  • Evaluating the Likelihood of Acceptance of a Machine Learning-Based Tool for Suicide Screening Within Our Epilepsy Clinic.
  • Suicide Prevention in Epilepsy: Development of a Disease Specific Model
  • The feasibility of project uplift for the treatment of psychogenic non-epileptic seizures

Andrew Smith, III, MD - Neuro Immunology

  • A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with primary progressive multiple sclerosis (PERSEUS)

Yinchen Song, PhD

  • High-density EEG in Neurological Disorders
  • Utility of intraoperative neurophysiological monitoring (IONM) during transcarotid artery revascularization (TCAR) procedure

Elijah Stommel, MD, PhD - Neuromuscular disease

  • Cerebral Spinal Fluid Bank for Research
  • ALS Gene x Environment x Time Interaction Analysis
  • Use of Collected Biospecimens for the Detection of Toxins and Preliminary Genetic Analyses in ALS
  • Geospatial and Toxicological Study of Massachusetts ALS Registry Patients
  • Case-control and Population Questionnaire Studying Environmental Risk Factors and Neurological Diseases
  • Northern New England Neurologic Biospecimen Repository

Rebecca Thompson, MD – Movement Disorders

  • A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of K0706 in Subjects with Early Parkinson's Disease.